Precision Diagnosis and Treatment
for Advanced Non–Small-Cell Lung Cancer
Lung cancer remains one of the most frequent and most deadly tumor entities.The correlation between smoking status and mortality from lung cancer has been confirmed, and a decrease in mortality after cessation of tobacco.
Although direct or environmental exposure to tobacco smoke is the predominant risk factor, inhalation of carcinogens through marijuana or hookah use also contributes to the risk of lung cancer. Additional risk factors include exposures to
radon, asbestos, diesel exhaust, and ionizing radiation. Increasing evidence suggests a correlation between lung cancer and chronic obstructive lung disease that
is independent of tobacco use and is probably mediated by genetic susceptibility.
Lung cancer in patients who have never smoked, accounting for approximately one quarter of all cases of lung cancer in the United States, has attracted growing interest because of treatable oncogenic alterations and the opportunity for individualized treatment.