Severe allergy asthma
Characterized by clinical features of allergy to specific aeroallergens and increased levels of total or specific immunoglobulin E (IgE). Therefore, allergic asthma is characterized by high IgE levels and positive skin prick tests or specific IgE in serum and clinical symptoms compatible with exposure to the allergen.
House dust mite and cat sensitization are the most prominent allergens associated with asthma severity.
severe sinus disease (odds ratio [OR] 3.7),
gastroesophageal reflux (OR, 4.9),
recurrent respiratory infections (OR, 6.9),
psychological dysfunctioning (OR, 10.8) and
obstructive sleep apnea (OR, 3.4).
Moreover, control is difficult to achieve in
obese patients and in patients who do not adhere to medication or healthy lifestyle recommendations.