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'normal ige'
Targeted therapy in the management of severe asthma patients High T2 High esinophil count and HIGH igE They are responsive to corticosteriods and biological Low T2 Normal esnophil count and normal IgE THEY ARE POOR TO STERIODS AND POOR RESPONSE TO BIOLOGICALS
Severe allergy asthma Characterized by clinical features of allergy to specific aeroallergens and increased levels of total or specific immunoglobulin E (IgE). Therefore, allergic asthma is characterized by high IgE levels and positive skin prick tests or specific IgE in serum and clinical symptoms compatible with exposure to the allergen. House dust mite and cat sensitization are the most prominent allergens associated with asthma severity. severe sinus disease (odds ratio [OR] 3.7), gastroesophageal reflux (OR, 4.9), recurrent respiratory infections (OR, 6.9), psychological dysfunctioning (OR, 10.8) and obstructive sleep apnea (OR, 3.4). Moreover, control is difficult to achieve in obese patients and in patients who do not adhere to medication or healthy lifestyle recommendations.
Abnormalities predisposing to obstructive sleep-disordered breathing (SDB) in childhood 1. Adenotonsillar hypertrophy, allergic rhinitis 2. Obesity 3. Craniofacial abnormalities in non-syndromic children: retrusive chin, steep mandibular plane, class II malocclusion 4. Maxillary hypoplasia in craniosynostosis syndromes 5. Mandibular hypoplasia without or with cleft palate 6. Neuromuscular disorders 7. Complex conditions: achondroplasia, Chiari malformation, Down syndrome, mucopolysaccharidoses, Prader–Willi syndrome
Normal Pleural cavity
050003E70201Sonographic character of Malignant lymph node Round shape Heterogeneous echigenecity Central necrosis Distinct borders Rich blood flow more than four d
Improvement in Obstructive Sleep Apnea With Weight Loss is Dependent on Body Position During Sleep obesity have normalization of the nonsupine AHI. For these patients, supine sleep avoidance may cure their OSA.
Obstructive Sleep Apnea and Diabetes Obstructive sleep apnea (OSA) is a chronic treatable sleep disorder and a frequent comorbidity in patients with type 2 diabetes. Cardinal features of OSA, including intermittent hypoxemia and sleep fragmentation, have been linked to abnormal glucose metabolism. The relationship between OSA and type 2 diabetes may be bidirectional in nature given that diabetic neuropathy can affect central control of respiration and upper airway neural reflexes promoting sleep-disordered breathing. Despite the strong association between OSA and type 2 diabetes, the effect of treatment with continuous positive airway pressure (CPAP) on markers of glucose metabolism has been conflicting. Variability with CPAP adherence may be one of the key factors behind these conflicting results. Lastly, accumulated data suggests an association between OSA and type 1 diabetes as well as gestational diabetes.
What Is Obstructive Sleep Apnea in Adults? Obstructive sleep apnea (OSA) is a common problem that affects a person’s breathing during sleep. A person with OSA has times during sleep in which air cannot flow normally into the lungs. The block in airflow (obstruction) is usually caused by the collapse of the soft tissues in the back of the throat (upper airway) and tongue during sleep.
Current treatment recommendations for adults and children beyond corticosteroids and their combinations, including clinical data on the use of anti-immunoglobulin E (IgE) therapy for severe allergic asthma