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Targeted therapy in the management of severe asthma patients High T2 High esinophil count and HIGH igE They are responsive to corticosteriods and biological Low T2 Normal esnophil count and normal IgE THEY ARE POOR TO STERIODS AND POOR RESPONSE TO BIOLOGICALS
Severe allergy asthma Characterized by clinical features of allergy to specific aeroallergens and increased levels of total or specific immunoglobulin E (IgE). Therefore, allergic asthma is characterized by high IgE levels and positive skin prick tests or specific IgE in serum and clinical symptoms compatible with exposure to the allergen. House dust mite and cat sensitization are the most prominent allergens associated with asthma severity. severe sinus disease (odds ratio [OR] 3.7), gastroesophageal reflux (OR, 4.9), recurrent respiratory infections (OR, 6.9), psychological dysfunctioning (OR, 10.8) and obstructive sleep apnea (OR, 3.4). Moreover, control is difficult to achieve in obese patients and in patients who do not adhere to medication or healthy lifestyle recommendations.
Abnormalities predisposing to obstructive sleep-disordered breathing (SDB) in childhood 1. Adenotonsillar hypertrophy, allergic rhinitis 2. Obesity 3. Craniofacial abnormalities in non-syndromic children: retrusive chin, steep mandibular plane, class II malocclusion 4. Maxillary hypoplasia in craniosynostosis syndromes 5. Mandibular hypoplasia without or with cleft palate 6. Neuromuscular disorders 7. Complex conditions: achondroplasia, Chiari malformation, Down syndrome, mucopolysaccharidoses, Prader–Willi syndrome
050003E70201Sonographic character of Malignant lymph node Round shape Heterogeneous echigenecity Central necrosis Distinct borders Rich blood flow more than four d
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